SPRAVATO® (esketamine)

A New Option for Difficult to Treat Depression

If you’ve tried multiple antidepressants without meaningful relief, you are not alone. For some patients, traditional medications simply aren’t enough. Spravato® (esketamine) is an FDA-approved treatment designed specifically for adults with difficult to treat depression.

At Restoration Psychiatry, Spravato is administered safely under the direct supervision of our certified providers in a comfortable, private clinical setting.

What Is Spravato?

Spravato is a prescription nasal spray medication approved by the U.S. Food and Drug Administration (FDA) for:

• Treatment-Resistant Depression (TRD) in adults

• Major Depressive Disorder (MDD) with suicidal thoughts or actions (in combination with an oral antidepressant)

Unlike traditional antidepressants that primarily target serotonin, Spravato works on the glutamate system, a different pathway in the brain, and may provide relief more quickly for some patients.

Who May Be a Candidate?

You may qualify for Spravato if:

• You are 18 years or older

• You have tried at least two antidepressants without adequate improvement

• You continue to experience moderate to severe depressive symptoms

A comprehensive evaluation with one of our providers is required to determine eligibility.

What to Expect

1. Evaluation Appointment
We will review your treatment history, symptoms, and determine if Spravato is appropriate for you.

2. In-Office Administration
Spravato is self-administered as a nasal spray under provider supervision.

3. Monitoring Period
You will remain in the office for at least 2 hours after each treatment while our team monitors you for safety and comfort.

4. Treatment Schedule

• Weeks 1–4: Typically twice weekly

• Weeks 5–8: Usually once weekly

• Maintenance: Every 1–2 weeks depending on response

You will need someone to drive you home after each treatment.

Safety & REMS Program

Spravato is only available through a restricted safety program called the REMS (Risk Evaluation and Mitigation Strategy). Restoration Psychiatry is a certified Spravato treatment site.

Our providers carefully screen and monitor each patient to ensure treatment is appropriate and safe.

Why Choose Restoration Psychiatry?

• Experienced psychiatric providers trained in Spravato administration

• Calm, private treatment rooms

• Close monitoring and individualized care

• Clear expectations and structured treatment planning

• Coordination with your overall mental health treatment plan

We understand that considering Spravato can feel like a big step. Our goal is to provide thorough education, thoughtful evaluation, and a safe environment where you feel supported throughout the process.

Ready to Learn More?

• If you are a current patient, please email info@restorationpsychcare.com or bring Spravato up to your provider during an appointment.

• If you are not a current patient of Restoration Psychiatry and would like to seek Spravato treatment with us, follow the link below to our new patient application.